Patients should be cautioned that methadone, like other opioids, may produce orthostatic hypotension in ambulatory patients.Regardless of the dose determination strategy employed, methadone is most safely initiated and titrated using small initial doses and gradual dose adjustments.Since the metabolism of methadone is mediated primarily by CYP3A4 i

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. You may also experience withdrawal symptoms.Published animal data have reported increased neonatal mortality hinein the offspring of male rodents that were treated with methadone prior to mating. Rein these studies, the femal

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.Methadone produces a significant regression of sex accessory organs and testes of male mice and rats. Additional data have been published